THERAPY DOSSIER · th-1c73740c3033

Human placental pericytes, either cobalt chloride stimulated (HIF-activated) or naive

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32608116 ↗2020Mixed findings

Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats.

RatSpinal cord injuryHemisection / partialMale and femaleInjection into the site of spinal cord transectionAcute delivery at the time of injury on postnatal day 3

Model: Thoracic hemi-section of the spinal cord in rat pups on postnatal day 3

HIF-activated pericytes increased vascular density in males but did not improve motor function in either sex, whereas non-HIF-activated pericytes improved motor recovery in both sexes (males 2.722 plus or minus 0.31-fold, females 3.824 plus or minus 0.58-fold score improvement, P less than 0.05) wi…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

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