Protective Effect of Vitamin C against Infancy Rat Corneal Injury Caused by Acute UVB Irradiation.
RatRadiationSprague-DawleyMalen = 36 infant rats, 12 per group; subgroup n = 3 for histology,…Intraperitoneal injection40 mg/kg per dayConcurrent with the 7 day UVB irradiation period
Model: Acute corneal injury from UVB irradiation of the eyes at 8 J/cm2, 15 min per day for 7 days, in infant rats
Vitamin C reduced corneal desquamation and neovascularisation area, lowered central corneal thickness (260.2 plus or minus 30.7 micrometres versus 381.4 plus or minus 70.8 in the UVB group and 198.0 plus or minus 9.9 in controls), reduced neutrophil infiltration and serum inflammatory and lipid per…
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