Nutraceutical · Supplement; provides a source of ascorbic acid and restores depleted ascorbic acid resources (FDA label).
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Critically Ill Patients · Cardiac Surgery · Trauma · Subarachnoid Hemorrhage
Enrolment: 200 · Results not recorded
Spinal Cord Injuries · Endothelial Dysfunction
Enrolment: 48 · Results not recorded
Iron Deficiency Anemia
Enrolment: 60 · Results not recorded
Stroke · Bruises · Skin Lesions
Enrolment: 400 · Results not recorded
Prehypertension · Hypertension
Enrolment: 44 · Results not recorded
Sepsis · Vitamin C · Intensive Care Unit · COVID-19 · Pandemic · Coronavirus
Enrolment: 872 · Results not recorded
Prostate Cancer · Castration-resistant Prostate Cancer
Enrolment: 4 · Results not recorded
Shock
Enrolment: 11 · Results not recorded
Melasma
Enrolment: 122 · Results not recorded
Skin Condition · Anti-Oxidative Stress
Enrolment: 30 · Results not recorded
Pneumonitis · Coronavirus Infection
Enrolment: 80 · Results not recorded
Postoperative Pain, Acute
Enrolment: 90 · Results not recorded
Sepsis
Enrolment: 80 · Results not recorded
Sepsis
Enrolment: 80 · Results not recorded
Iron · Cerebral Blood Flow · Energy Metabolism · Cognitive Function
Enrolment: 78 · Results not recorded
8 studies reported at therapy level; 13 evidence entries itemised.
Model: Acute corneal injury from UVB irradiation of the eyes at 8 J/cm2, 15 min per day for 7 days, in infant rats
Vitamin C reduced corneal desquamation and neovascularisation area, lowered central corneal thickness (260.2 plus or minus 30.7 micrometres versus 381.4 plus or minus 70.8 in the UVB group and 198.0 plus or minus 9.9 in controls), reduced neutrophil infiltration and serum inflammatory and lipid per…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
Model: Acute diazinon (organophosphate) exposure at 100 mg/kg causing multi-tissue oxidative injury
Diazinon raised superoxide dismutase, glutathione-S-transferase and malondialdehyde and lowered cholinesterase, lactate dehydrogenase and glutathione; both prophylactic and therapeutic vitamin C ameliorated these changes, most notably in brain tissue, although values did not return to normal.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Methotrexate-induced testicular injury with methotrexate 10 mg/kg/day intraperitoneally
Vitamin C reduced methotrexate-induced testicular histological injury, with significantly better tubular diameter, germinal epithelial thickness and biopsy score when given before rather than after methotrexate.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Carbon tetrachloride (CCl4)-induced acute liver injury
Vitamin C supplementation improved vital signs of CCl4-lesioned mice and produced a dose-dependent reduction of hepatomegaly. Serum ALT and AST were lowered and blood plasma lactic acid decreased. Hepatic SOD and GSH-PX activities increased while MDA content fell. Hepatotoxic injury was attenuated…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Common bile duct ligation-induced chronic liver injury (hepatitis at day 8, cirrhosis at day 29)
Ascorbate did not influence hepatitis, oxidative stress, fibrosis or haemodynamic parameters in bile duct ligated rats, and intrahepatic and collateral vasoresponsiveness, mesenteric angiogenesis and shunting severity were also unaffected.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Permanent middle cerebral artery occlusion
Ascorbic acid alone (p < 0.001) or combined with the thrombolytic (p < 0.05) significantly reduced infarct volume compared with control or thrombolytic alone. Blood-brain barrier permeability (p < 0.05), matrix metalloproteinase 9 (p < 0.05 versus control, p < 0.01 versus thrombolytic) and brain oe…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Contusion spinal cord injury
Spinal cord injury increased 5-hydroxymethylcytosine and Tet family expression in the brain motor cortex. Ascorbic acid at 100 mg/kg further enhanced 5-hydroxymethylcytosine and Tet1, Tet2 and Tet3 expression, reduced lesion cavity area and ED1-positive macrophage and microglia numbers, promoted 5H…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Standardised spinal cord contusion injury
High-dose ascorbic acid improved BBB score at days 14 and 28 and improved gait parameters compared with control and normal dose. Both doses reduced necrosis at the injury site.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
