Examination of the Effects of Celecoxib on Postmastectomy Seroma and Wound Healing.
RatWoundWistarFemalen = 20 rats randomised, 10 per group; 19 analysed after exclusi…Intraperitoneal20 mg/kg/day (0.25 cc/250 g)First dose given intraoperatively after haemostasis before flap closure, then d…
Model: Unilateral mastectomy with axillary lymph node dissection (Harada model) via midline incision, skin and subcutaneous flap elevation and excision of pectoralis major, producing postoperative seroma
Mean seroma volume 1.19 +/- 0.074 ml in controls versus 0.333 +/- 0.024 ml with celecoxib (p<=0.001), and seroma fluid IL-1 beta significantly lower with celecoxib (p=0.014). VEGF did not differ (p=0.447) and no histopathological parameter differed except congestion, which was significantly higher…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.