The contribution of stem cell factor and granulocyte colony-stimulating factor in reducing neurodegeneration and promoting neurostructure network reorganization after traumatic brain injury.
MouseTBIControlled cortical impactC57BLMaleTreatment initiated 3 weeks after induction of injury
Model: Controlled cortical impact causing severe damage to the motor cortex of the right hemisphere
Combined SCF and G-CSF started 3 weeks post-injury significantly improved impaired spatial learning at 6 weeks after treatment, reduced neurodegeneration in contralateral frontal cortex and hippocampal CA1, increased MAP2 apical dendrites in peri-injury cortex and prevented axonal overgrowth, but m…
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