Inhibition of eIF2 Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury.
MouseChemical/toxinBALB/cMalen = n = 10 per group for the carbon tetrachloride and chemical…Intraperitoneal for PBA, salubrinal and ISRIB; tail vein injection for the adeno-associated virus vectorPBA 150 mg/kg body weight (vehicle phosphate buffered salin…Pretreatment 2 h before carbon tetrachloride; viral transduction 4 weeks before…
Model: Carbon tetrachloride induced acute liver injury, 10 mL/kg body weight of a mixture of 25 per cent CCl4 in 75 per cent olive oil, intraperitoneally
Pretreatment with 4-phenylbutyric acid reduced carbon tetrachloride induced endoplasmic reticulum stress markers, cleaved caspase-3, serum alanine aminotransferase and the extent and severity of hepatic necrosis, whereas ISRIB or DnaJC3 overexpression worsened injury; salubrinal was similarly prote…
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