Trial title not recorded
Brain Neoplasms · Neuroblastoma
Enrolment: 35 · Results not recorded
Loading the evidence…
Drug · No mechanism_of_action record in ChEMBL for CHEMBL1746; sodium phenylbutyrate is flagged as a prodrug in ChEMBL (prodrug=1). Ammonia-scavenger / chemical-chaperone activity is literature-reported, not asserted by the ChEMBL MoA table.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Brain Neoplasms · Neuroblastoma
Enrolment: 35 · Results not recorded
Urea Cycle Disorders
Enrolment: 88 · Results not recorded
Urea Cycle Disorders
Enrolment: 60 · Results not recorded
Proteinuric Diseases
Enrolment: 26 · Results not recorded
Huntington's Disease
Enrolment: 60 · Results not recorded
Cystic Fibrosis
Enrolment: 16 · Results not recorded
Colorectal Cancer
Enrolment: 46 · Results not recorded
2-hydroxyglutaric Aciduria
Enrolment: 1 · Results not recorded
Parkinson's Disease
Enrolment: 38 · Results not recorded
Leukemia · Myelodysplastic Syndromes · Myelodysplastic/Myeloproliferative Diseases
Enrolment not recorded · Results not recorded
Leukemia · Myelodysplastic Syndromes · Myelodysplastic/Myeloproliferative Diseases
Enrolment not recorded · Results not recorded
Hepatic Encephalopathy · Urea Cycle Disorders
Enrolment: 32 · Results not recorded
Hyperammonemia
Enrolment: 8 · Results not recorded
Solid Tumors · Lymphoma
Enrolment: 34 · Results not recorded
Byler Disease
Enrolment not recorded · Results not recorded
7 studies reported at therapy level; 7 evidence entries itemised.
Model: Diffuse axonal injury model
Early treatment 5 min after injury inhibited the unfolded protein response and cell apoptosis and relieved anxiety disorder. Delayed treatment from 14 days post-injury restored endoplasmic reticulum stress and unfolded protein response gene expression but did not improve the psychiatric phenotype.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Carbon tetrachloride induced acute liver injury, 10 mL/kg body weight of a mixture of 25 per cent CCl4 in 75 per cent olive oil, intraperitoneally
Pretreatment with 4-phenylbutyric acid reduced carbon tetrachloride induced endoplasmic reticulum stress markers, cleaved caspase-3, serum alanine aminotransferase and the extent and severity of hepatic necrosis, whereas ISRIB or DnaJC3 overexpression worsened injury; salubrinal was similarly prote…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Acute whole-body gamma irradiation at 7 to 11.5 Gy, with a 30-day lethality endpoint; parallel in vitro work in human osteoblast (HOS) cells
Oral phenylbutyrate before irradiation gave a dose reduction factor of 1.25 (p = 0.001) and after irradiation a dose reduction factor of 1.18 (p = 0.05). Treatment was associated with significant elevations in neutrophils and platelets, attenuated DNA damage, and restored radiation-reduced acetylat…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Renal ischaemia-reperfusion by bilateral renal pedicle occlusion with an atraumatic microvascular clamp for 45 min followed by reperfusion; body temperature maintained at 37 degrees C; reperfusion assessed at 8, 12, 16, 24 and 48 h, with the main studies at 24 h
4-PBA and TUDCA attenuated tubular epithelial apoptosis, histological damage and renal functional impairment after ischaemia-reperfusion, and N-acetylcysteine reduced GRP78, XBP1 and CHOP expression. Cx32 deletion reduced ROS spread and TUNEL-positive cells compared with wild-type littermates.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct
4-Phenylbutyric acid reduced pancreatic and intestinal injury, inflammatory cytokines, barrier markers and endoplasmic reticulum stress-driven epithelial apoptosis, although amylase, lipase, caspase-8 and caspase-9 changed only slightly.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: T9 laminectomy followed by clip-compression crush of the spinal cord with a vascular clip at 30 g force for 2 minutes under chloral hydrate anaesthesia; sham had identical surgery without compression
4-phenylbutyric acid reduced barrier permeability, preserved tight and adherens junction proteins and lowered endoplasmic reticulum stress and autophagy markers, whereas chloroquine worsened permeability and junction protein loss and abolished the benefit of 4-phenylbutyric acid when co-administere…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis induced by standardised retrograde infusion of 5% sodium taurocholate saline solution, 1 mL/kg body weight, into the biliopancreatic duct at 0.1 mL/min after laparotomy
4-PBA pretreatment significantly reduced pancreatic histopathological score, serum TNF-alpha, IL-1 beta and insulin, raised serum glucose, reduced islet expression of BiP, ORP150, CHOP and caspase-3, increased islet insulin staining, and ameliorated beta-cell ultrastructural damage (all p<0.05). Re…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.