Tubular transcriptional co-activator with PDZ-binding motif protects against ischemic acute kidney injury.
MouseIschaemia-reperfusionRenalC57BL
Model: Renal ischaemia-reperfusion injury; in vitro hypoxia-treated human renal proximal tubular epithelial cells
Chloroquine increased TAZ in the renal cortex and tubules, improved renal function and attenuated tubular injury and apoptosis after ischaemia-reperfusion, whereas TAZ siRNA and verteporfin lowered TAZ, worsened renal failure and aggravated tubular apoptosis, indicating a renoprotective role for tu…
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