Does zinc supplementation enhance efficacy of chloroquine/hydroxychloroquine in COVID-19?
COVID-19
Enrolment: 191 · Results not recorded
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Drug · Ferriprotoporphyrin IX inhibitor; Ferriprotoporphyrin IX binding agent
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
COVID-19
Enrolment: 191 · Results not recorded
Breast Cancer
Enrolment: 60 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Renal ischaemia-reperfusion injury; in vitro hypoxia-treated human renal proximal tubular epithelial cells
Chloroquine increased TAZ in the renal cortex and tubules, improved renal function and attenuated tubular injury and apoptosis after ischaemia-reperfusion, whereas TAZ siRNA and verteporfin lowered TAZ, worsened renal failure and aggravated tubular apoptosis, indicating a renoprotective role for tu…
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Model: Penetrating stab wound to adult cerebral cortex
Chloroquine or colchicine reduced mononuclear phagocyte numbers in damaged brain and blocked reactive astrogliosis and neovascularisation, but also slowed debris clearance from the wound site. Dexamethasone neither reduced inflammatory cell numbers nor affected phagocytosis, astrogliosis, neovascul…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.
Model: Carbon tetrachloride-induced acute liver injury by intraperitoneal injection of 0.3 percent carbon tetrachloride at 10 mL per kg in olive oil (sub-lethal), with a separate lethality study using 2.5 percent carbon tetrachloride at 10 mL per kg
Chloroquine pre-treatment at 50 mg per kg lowered serum transaminases and histological injury scores at all time points, reduced hepatic and serum HMGB1, tumour necrosis factor alpha and interleukin-6, and raised 24 hour survival after lethal carbon tetrachloride from 40 to 80 percent.
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Model: Severe stroke injury (focal cerebral ischaemia)
Chloroquine prevented ganglioside dysregulation at 3 days and partially prevented complex ganglioside depletion at 21 days after stroke, protected primary cortical neurons against exogenous GM3 toxicity, prevented forelimb motor deficits, and was associated with decreased inflammation and neurodege…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute spinal cord injury
Chloroquine improved locomotor function and inhibited autophagy, inflammation and endoplasmic reticulum stress after acute spinal cord injury in rats.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.