Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril.
RatRadiationWAG/RijCmcrFemalen = Wounds only n = 7, wounds with lisinopril n = 7, 13 Gy only…Oral, dissolved in drinking waterStarted 7 days after irradiation
Model: 13 Gy leg-out partial body X-irradiation (320 kVp, 13 mAs, 1.4 mm Cu half value layer, dose rate 1.75 Gy per minute, shielded hind limb receiving about 2 Gy) combined with 8 mm diameter full-thickness skin wounds made within 2 hours of irradiation
Wounding exacerbated morbidity between 5 and 14 days post-irradiation during the acute radiation syndrome phase and irradiation delayed wound healing, while wounding did not alter delayed morbidity from pneumonitis or nephropathy after 30 days. Lisinopril did not improve wound healing but markedly…
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