Valsartan + Lisinopril vs Monotherapy in Hypertensive Patients With Microalbuminuria
Hypertension
Enrolment: 134 · Results not recorded
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Drug · Angiotensin-converting enzyme inhibitor (INHIBITOR)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Hypertension
Enrolment: 134 · Results not recorded
Acute Coronary Syndrome · Hypertension
Enrolment: 80 · Results not recorded
Fasting
Enrolment: 40 · Results not recorded
Prostate Cancer · Radiation Toxicity · Urinary Complication
Enrolment: 30 · Results not recorded
Healthy
Enrolment: 36 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: 13 Gy leg-out partial body X-irradiation (320 kVp, 13 mAs, 1.4 mm Cu half value layer, dose rate 1.75 Gy per minute, shielded hind limb receiving about 2 Gy) combined with 8 mm diameter full-thickness skin wounds made within 2 hours of irradiation
Wounding exacerbated morbidity between 5 and 14 days post-irradiation during the acute radiation syndrome phase and irradiation delayed wound healing, while wounding did not alter delayed morbidity from pneumonitis or nephropathy after 30 days. Lisinopril did not improve wound healing but markedly…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: 13 Gy leg-out partial-body irradiation with 320 kVp x-rays, with one hind limb shielded and the head additionally shielded in some old rats
Lisinopril mitigated radiation nephropathy in juvenile and old rats of both sexes and pneumonitis in juvenile females, raising juvenile survival from 0% to 88%, although old-rat survival curves did not differ.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: 13 Gy partial-body irradiation sparing one hind leg
Lisinopril prevented the transient pulmonary hypertension seen at 50 days and raised survival from 41% to 86%, but was associated with left ventricular remodelling at 50 days and signs of pulmonary hypertension by 100 days.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Partial-body irradiation with one hind leg shielded (leg-out PBI), single doses of 11 to 13.5 Gy delivered by XRAD 320 kVp orthovoltage x-ray at 1.75 Gy per minute; shielded leg received 2 Gy
After 12.5 Gy leg-out PBI, 9 of 10 untreated rats were morbid by 150 days whereas all lisinopril-treated rats survived with blood urea nitrogen below 55 mg/dL. Saline plus enrofloxacin reduced 30-day morbidity after 13 Gy (p<0.01), and adding lisinopril mitigated overall morbidity to beyond 150 day…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.