Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.

Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.

Model: Radiation-induced acute and chronic intestinal injury in mice, with a fractionated abdominal irradiation model of HCT116 and HT29 tumour grafts

Metformin alleviated radiation-induced acute and chronic intestinal toxicity through AMPK-dependent optimisation of mitophagy, while increasing the radiosensitivity of P53-mutant colorectal tumours in vitro and in vivo.

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