Doxycycline improves traumatic brain injury outcomes in a murine survival model.
MouseTBIControlled cortical impactC57BL/6JMalen = 40 mice in total: 15 sham, 15 traumatic brain injury, 10 tr…20 mg/kgFirst dose 2 hours after injury
Model: Moderate controlled cortical impact traumatic brain injury
Doxycycline-treated mice had significantly improved modified neurological severity and wire grip scores at postoperative day 1 and improved ataxia scores by days 3 and 6 (all p < 0.05), with no significant difference in rate of weight change between groups.
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