A Randomized, Double-Blind, Multi-Center Comparative Effectiveness Study of Spironolactone Versus Doxycycline Hyclate for the Treatment of Acne in Women
Acne
Enrolment: 350 · Results not recorded
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Drug · Bacterial 70S ribosome inhibitor (16S rRNA binding site); also inhibits matrix metalloproteinases MMP-1, MMP-7, MMP-8 and MMP-13, which ChEMBL notes is the primary action at concentrations reached in the human body
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acne
Enrolment: 350 · Results not recorded
Duodenal Ulcer Due to Helicobacter Pylori
Enrolment: 184 · Results not recorded
Acne Vulgaris
Enrolment: 30 · Results not recorded
Sexually Transmitted Infection
Enrolment: 24 · Results not recorded
Periodontal Disease · Type 2 Diabetes Mellitus
Enrolment: 113 · Results not recorded
Helicobacter Pylori Infection
Enrolment: 80 · Results not recorded
Pulmonary Disease, Chronic Obstructive
Enrolment: 140 · Results not recorded
Neuroborreliosis, Borrelia Burgdorferi
Enrolment: 121 · Results not recorded
Chronic Obstructive Pulmonary Disease (COPD)
Enrolment: 200 · Results not recorded
Haematological Malignancy · Hypogammaglobulinemia
Enrolment: 300 · Results not recorded
Acne · Inflammation
Enrolment: 100 · Results not recorded
Lymphedema · Lymphatic Filariasis · Filariasis
Enrolment: 235 · Results not recorded
Crohn's Disease
Enrolment: 59 · Results not recorded
Chronic Endometritis
Enrolment: 90 · Results not recorded
Aneurysm
Enrolment: 261 · Results not recorded
Larynx · Lip · Oral Cavity · Pharynx
Enrolment: 7 · Results not recorded
COVID-19 · Coronavirus Infection · SARS-CoV2
Enrolment: 31 · Results not recorded
Tick-Bite; Fever · Tick Fever · Tick-Borne Diseases · Encephalitis, Tick-Borne · Tick Bites
Enrolment: 0 · Results not recorded
Cirrhosis · Spontaneous Bacterial Peritonitis
Enrolment: 841 · Results not recorded
Rheumatoid Arthritis
Enrolment: 160 · Results not recorded
7 studies reported at therapy level; 7 evidence entries itemised.
Model: Moderate controlled cortical impact traumatic brain injury
Doxycycline-treated mice had significantly improved modified neurological severity and wire grip scores at postoperative day 1 and improved ataxia scores by days 3 and 6 (all p < 0.05), with no significant difference in rate of weight change between groups.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Surgical incised wound of 10 by 10 mm on the dorsum under ketamine and xylazine anaesthesia, and gastric ulcer induced by oral absolute ethanol 98.9 per cent at 5 mL/kg after 24 h fasting
Both nanocomposites gave complete wound closure by day 18 compared with about 24 days in other groups and markedly lowered the ethanol ulcer index, outperforming the free antibiotics, with histology confirming the effect.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Angiotensin II infusion induced acute aortic dissection and rupture in Lnk (SH2B3) deficient mice, with adoptive transfer of Lnk-/- leukocytes into Rag1-/- recipients
Doxycycline prevented early aortic neutrophil accumulation and significantly reduced the incidence of aortic dissection and rupture in angiotensin II infused Lnk deficient mice, while LNK loss itself markedly increased susceptibility.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.
Model: Intratracheal LPS-induced lung injury
Doxycycline produced a partial reduction in LPS-induced heparan sulfate shedding but only a non-significant trend towards decreased alveolar permeability, indicating it was not sufficient to rescue epithelial barrier function after intratracheal LPS-induced lung injury.
Extraction: extract · Supplied extraction confidence: 0.45. Machine-extracted fields require source verification.
Model: Noise induced cochlear injury from acoustic overstimulation
Short term doxycycline reduced hearing loss and sensory cell death, whereas 7 day treatment worsened hearing sensitivity and potentiated noise induced hearing loss.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: 30 per cent total body surface area full-thickness burn; parallel in vitro studies using rat lung microvascular endothelial cells treated with sera from sham or burned animals
MMP-9 levels rose after burn injury. Burn serum significantly increased endothelial monolayer permeability and disrupted the adherens junction complex, and both effects were attenuated by doxycycline and by a specific MMP-9 inhibitor (p<0.05). Intravital microscopy confirmed microvascular hyperperm…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Ventilator-induced lung injury (high-pressure ventilation)
MMP inhibition with doxycycline delayed epithelial repair after ventilator-induced lung injury, indicating MMP-2 is required for lung recovery.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.