Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation.
RatSpinal cord injuryContusionSprague-DawleyFemaleIntraperitoneal5, 100 or 200 mg/kg daily; 100 mg/kg was the most effective…Started 30 minutes after spinal cord injury
Model: Contusion spinal cord injury
Spinal cord injury increased 5-hydroxymethylcytosine and Tet family expression in the brain motor cortex. Ascorbic acid at 100 mg/kg further enhanced 5-hydroxymethylcytosine and Tet1, Tet2 and Tet3 expression, reduced lesion cavity area and ED1-positive macrophage and microglia numbers, promoted 5H…
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