Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction.
RatOtherSprague-DawleyMale
Model: Ileus (intestinal obstruction) rat model, with in vitro assays of somatostatin secretion, IL-6 secretion and wound healing
An eleven-ingredient active compound combination was bioequivalent to Da-Cheng-Qi decoction to some extent across intestinal motility, inflammation and injury readouts and is proposed as a set of quality markers, with PI3K/AKT identified as a probable mediating pathway.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.