The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury.
MouseChemical/toxinC57BL/6 wild type; FXR knockout (B6.129X1(FVB)-Nr1h4tm1Gonz/J); liver-specific SIRT1 knockout (SIRT1 floxed crossed with Alb-cre)MaleOral gavage, suspended in 0.5 per cent CMC-NaIn vivo imperatorin dose not stated numerically, described…Prevention protocol: daily gavage for 5 days before acetaminophen challenge on…
Model: Acute liver injury induced by a single intraperitoneal overdose of acetaminophen at 300 mg/kg after overnight fasting, with separate lipopolysaccharide (25 mg/kg) and survival models
Imperatorin reduced acetaminophen- and lipopolysaccharide-induced mortality, lowered serum ALT and AST and reduced centrilobular necrosis, with the largest effect at the high dose. It restored FXR, SHP and BSEP expression, reduced pro-inflammatory cytokines and COX2, restored GSH/GSSG, Nrf2 and SOD…
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