THERAPY DOSSIER · th-ea0e0ff98d2c

Imperatorin, a furanocoumarin from Angelica dahurica

Nutraceutical · Furanocoumarin (psoralen-type) natural product. ChEMBL holds no mechanism-of-action record, and max_phase is -1 (unknown clinical phase), so no clinical development stage can be asserted. No relevant ClinicalTrials.gov records: the Angelica dahurica keyword search returned only unrelated multi-herb TCM formula trials, which were excluded.

Not approved Suggest a correction

Evidence & regulatory context

Mechanism: Furanocoumarin (psoralen-type) natural product. ChEMBL holds no mechanism-of-action record, and max_phase is -1 (unknown clinical phase), so no clinical development stage can be asserted. No relevant ClinicalTrials.gov records: the Angelica dahurica keyword search returned only unrelated multi-herb TCM formula trials, which were excluded.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Preclinical/no trial
ChEMBL record: CHEMBL453805 ↗
ChEMBL max phase: -1 / 4 (development scale, not regulatory approval)
Synonyms: Imperatorin; Ammidin; Marmelosin; 8-isoamylenoxypsoralen; NSC-402949; Pentosalen
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32454943 ↗2020Reported benefit

The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury.

MouseChemical/toxinC57BL/6 wild type; FXR knockout (B6.129X1(FVB)-Nr1h4tm1Gonz/J); liver-specific SIRT1 knockout (SIRT1 floxed crossed with Alb-cre)MaleOral gavage, suspended in 0.5 per cent CMC-NaIn vivo imperatorin dose not stated numerically, described…Prevention protocol: daily gavage for 5 days before acetaminophen challenge on…

Model: Acute liver injury induced by a single intraperitoneal overdose of acetaminophen at 300 mg/kg after overnight fasting, with separate lipopolysaccharide (25 mg/kg) and survival models

Imperatorin reduced acetaminophen- and lipopolysaccharide-induced mortality, lowered serum ALT and AST and reduced centrilobular necrosis, with the largest effect at the high dose. It restored FXR, SHP and BSEP expression, reduced pro-inflammatory cytokines and COX2, restored GSH/GSSG, Nrf2 and SOD…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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Imperatorin, a furanocoumarin from Angelica dahurica