Human adipose-derived mesenchymal stem cells for acute and sub-acute TBI.
RatTBIControlled cortical impactSprague DawleyMalen = Behaviour: sham n = 10, injury plus vehicle n = 13, treatme…Intravenous, tail vein3 x 10 cells/kg as rendered in the retrieved text, exponent…Single dose at either 3 days or 14 days after controlled cortical impact
Model: Moderate to severe controlled cortical impact after 6 to 7 mm right-sided craniectomy, single impact at 3.1 mm deformation depth, 5.6 m/s velocity, 150 ms dwell time, 6 mm flat tip at 20 degrees from vertical, under isoflurane
Both dosing times significantly improved spatial learning and memory. Dosing at 3 days shortened latency and swim distance on test days 2 to 6, while dosing at 14 days shortened latency on days 2 and 6. In the probe trial the 14 day group spent more time in the platform quadrant than injured contro…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.