THERAPY DOSSIER · th-3804b2cc2687

Human adipose-derived mesenchymal stromal cells (HB-adMSC), single donor, passage 4

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: HB-adMSC; Hope Biosciences adipose derived mesenchymal stem cells
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03925649 ↗Injury indicationPhase not recordedno longer available

Individual patient expanded access IND of autologous HB-adMSCs for spinal cord injury

Spinal Cord Injury at C5-C7 Level

Enrolment not recorded · Results not recorded

NCT06056427 ↗Phase not recordedno longer available

Expanded access protocol of autologous HB-adMSCs for Parkinson's disease

Parkinson Disease

Enrolment not recorded · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32453741 ↗2020Reported benefit

Human adipose-derived mesenchymal stem cells for acute and sub-acute TBI.

RatTBIControlled cortical impactSprague DawleyMalen = Behaviour: sham n = 10, injury plus vehicle n = 13, treatme…Intravenous, tail vein3 x 10 cells/kg as rendered in the retrieved text, exponent…Single dose at either 3 days or 14 days after controlled cortical impact

Model: Moderate to severe controlled cortical impact after 6 to 7 mm right-sided craniectomy, single impact at 3.1 mm deformation depth, 5.6 m/s velocity, 150 ms dwell time, 6 mm flat tip at 20 degrees from vertical, under isoflurane

Both dosing times significantly improved spatial learning and memory. Dosing at 3 days shortened latency and swim distance on test days 2 to 6, while dosing at 14 days shortened latency on days 2 and 6. In the probe trial the 14 day group spent more time in the platform quadrant than injured contro…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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