Prostaglandin E receptor EP4 stimulates lymphangiogenesis to promote mucosal healing during DSS-induced colitis.
MouseChemical/toxinC57BL/6, with knockout animals also usedMaleDaily dosing from day 5 through day 13, that is after the dextran sulphate sodi…
Model: Acute colitis induced by dextran sulphate sodium in the drinking water for 5 days followed by normal water for a further 9 days
Post-treatment with the EP4 agonist improved disease activity, suppressed CD11b positive cell infiltration and decreased inflammatory cytokines, with upregulated lymphatic growth factors, increased percentage lymphatic vessel area and improved lymphatic drainage. The EP4 antagonist worsened colitis…
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