ONO-4819CD (rivenprost), an EP4 agonist, in mild to moderate ulcerative colitis
Ulcerative Colitis
Enrolment: 7 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Ulcerative Colitis
Enrolment: 7 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Acute colitis induced by dextran sulphate sodium in the drinking water for 5 days followed by normal water for a further 9 days
Post-treatment with the EP4 agonist improved disease activity, suppressed CD11b positive cell infiltration and decreased inflammatory cytokines, with upregulated lymphatic growth factors, increased percentage lymphatic vessel area and improved lymphatic drainage. The EP4 antagonist worsened colitis…
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