Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids.
MouseChemical/toxinSwissMaleIndomethacin intraperitoneal; hexamethonium intravenous by tail vein; the other agents intraperitonealIndomethacin 3 mg/kg; hexamethonium bromide 10 mg/kg; MK-59…All drugs given as pre-treatment before crotoxin: indomethacin 4.5 h before, he…
Model: Acute lung impairment and respiratory failure induced by subcutaneous crotoxin, the phospholipase A2 complex of Crotalus durissus terrificus venom, at 300 microgram/kg, being 1.3 times the measured LD50 of 229.6 microgram/kg, with a parallel dorsal air pouch model
Indomethacin and hexamethonium each increased survival, whereas MK-591, neostigmine, methyl-atropine and propranolol did not. Indomethacin, but not hexamethonium, blocked the early rise in vascular permeability and lung PGE2. Hexamethonium, but not indomethacin, blocked the late rise in myeloperoxi…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.