Magnesium Sulfate Versus Indomethacin for Preterm Labor
Labor, Premature
Enrolment not recorded · Results not recorded
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Drug · Cyclooxygenase inhibitor (INHIBITOR); direct interaction, disease efficacy true; non-selective COX-1/COX-2 NSAID.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Labor, Premature
Enrolment not recorded · Results not recorded
Obstetric Labor, Premature
Enrolment: 300 · Results not recorded
Tachycardia · Chronic Orthostatic Intolerance
Enrolment: 150 · Results not recorded
Cerebrovascular Circulation
Enrolment: 80 · Results not recorded
Preterm Labor
Enrolment: 11 · Results not recorded
6 studies reported at therapy level; 6 evidence entries itemised.
Model: Blunt chest trauma by free-dropping a hollow 200 g metal weight from 25.5, 38.3 or 51.2 cm onto the right thorax under anaesthesia after tracheotomy
Indomethacin reduced bronchoalveolar lavage total protein (1.06 plus or minus 0.39 versus 3.75 plus or minus 1.95 mg/mL, p = 0.006), alveolar FD-70 leak (0.23 plus or minus 0.19 versus 0.53 plus or minus 0.19 micrograms/mL, p = 0.02) and percentage polymorphonuclear leukocytes (13.33 plus or minus…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Gastric ulcer induced by submucosal injection of 20 per cent acetic acid (0.03 ml) at the antral-oxyntic border
Repeated indomethacin markedly delayed natural healing of acetic acid ulcers and reduced gastric mucosal prostaglandin E2 for at least 12 h after dosing. Co-administered prostaglandin E2 prevented the delay, and prostaglandin E2 at 3 mg/kg twice daily also accelerated natural healing and reduced hi…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Asphyxiation in a nitrogen atmosphere for 3 minutes or 3 minutes 40 seconds, with or without resuscitation using 95 per cent oxygen and 5 per cent carbon dioxide
Asphyxia for 3 minutes 40 seconds raised brain prostaglandin E2 without changing prostaglandin F2 alpha, while asphyxia followed by resuscitation raised prostaglandin F2 alpha with prostaglandin E2 unchanged. Indomethacin pretreatment lowered both prostaglandins below non-asphyxiated control levels…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute lung impairment and respiratory failure induced by subcutaneous crotoxin, the phospholipase A2 complex of Crotalus durissus terrificus venom, at 300 microgram/kg, being 1.3 times the measured LD50 of 229.6 microgram/kg, with a parallel dorsal air pouch model
Indomethacin and hexamethonium each increased survival, whereas MK-591, neostigmine, methyl-atropine and propranolol did not. Indomethacin, but not hexamethonium, blocked the early rise in vascular permeability and lung PGE2. Hexamethonium, but not indomethacin, blocked the late rise in myeloperoxi…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Chronic constriction injury of the right nervus ischiadicus, adapted from Bennett and Xie, with one loose 4.0 chromic gut ligature placed about 7 mm proximal to the trifurcation via blunt dissection through biceps femoris; anaesthesia ketamine 92 mg/kg plus xylazine 9.2 mg/kg
Indomethacin attenuated mechanical allodynia on days 1, 2 and 4 after chronic constriction injury (P<0.05 at 15 and 30 min post-injection) but had no effect at days 7, 14, 21 or 28. Contralateral paw withdrawal thresholds were unchanged.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Renal ischaemia-reperfusion injury induced by clamping the left renal pedicle
Indomethacin showed a dose-dependent renoprotective effect. Mice given 5 mg/kg had a marked reduction in serum creatinine and significantly less tubular damage; 5 and 7 mg/kg reduced renal tumour necrosis factor alpha and serum interleukin 6; 3 and 5 mg/kg reduced the thromboxane B2 to 6-keto-prost…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.