Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
MouseOtherC57BL/6 wild type and cathepsin S knockoutMaleOral, the compound being described as orally available; specific route and dose not stated in the abstractGiven after establishment of allodynia following spared nerve injury, a reversa…
Model: Spared nerve injury model of chronic neuropathic pain, with an acute mild thermal injury model used in parallel
JNJ-39641160 dose-dependently blocked invariant chain proteolysis and inhibited T-cell activation and antibody production to a vaccine antigen. It fully reversed tactile allodynia in wild type mice after spared nerve injury but was completely ineffective in cathepsin S knockout mice, which themselv…
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