THERAPY DOSSIER · th-0cee71582d94

JNJ-39641160, a non-covalent, potent, selective, orally available and peripherally restricted cathepsin S inhibitor

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00425321 ↗PHASE2completed

RWJ-445380 cathepsin S inhibitor in active rheumatoid arthritis despite methotrexate

Rheumatoid Arthritis

Enrolment: 259 · Results not recorded

NCT01947738 ↗PHASE1completed

Ascending oral doses of VBY-891 (cathepsin S inhibitor) in healthy subjects

Healthy

Enrolment: 89 · Results not recorded

NCT01911637 ↗PHASE1completed

Single ascending oral doses of VBY-036 (cathepsin S inhibitor) in healthy subjects

Healthy

Enrolment: 48 · Results not recorded

NCT01892891 ↗PHASE1completed

Multiple ascending oral doses of VBY-036 (cathepsin S inhibitor) in healthy subjects

Healthy

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32437743 ↗2020Mixed findings

Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.

MouseOtherC57BL/6 wild type and cathepsin S knockoutMaleOral, the compound being described as orally available; specific route and dose not stated in the abstractGiven after establishment of allodynia following spared nerve injury, a reversa…

Model: Spared nerve injury model of chronic neuropathic pain, with an acute mild thermal injury model used in parallel

JNJ-39641160 dose-dependently blocked invariant chain proteolysis and inhibited T-cell activation and antibody production to a vaccine antigen. It fully reversed tactile allodynia in wild type mice after spared nerve injury but was completely ineffective in cathepsin S knockout mice, which themselv…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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