Fingolimod Attenuates Lung Injury and Cardiac Dysfunction after Traumatic Brain Injury.
MouseTBIControlled cortical impactC57BL/6MaleIntraperitoneal1 mg/kg2 hours after controlled cortical impact
Model: Controlled cortical impact traumatic brain injury with secondary acute lung injury and cardiac dysfunction
Fingolimod reduced inflammatory cytokine production, neutrophil infiltration, bronchoalveolar lavage protein leakage and lung wet/dry weight ratio at 3 days after traumatic brain injury, and reduced cardiac inflammation, apoptosis, fibrosis and histological microstructural change. Cardiac function…
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