Efficacy and Safety of Fingolimod in Minimal Invasive Treatment of Intracerebral Hemorrhage
Intracerebral Hemorrhage
Enrolment: 40 · Results not recorded
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Drug · Sphingosine 1-phosphate receptor agonist; Sphingosine 1-phosphate receptor binding agent
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Intracerebral Hemorrhage
Enrolment: 40 · Results not recorded
Relapsing-remitting Multiple Sclerosis
Enrolment: 133 · Results not recorded
Relapsing Remitting Multiple Sclerosis RRMS
Enrolment: 87 · Results not recorded
Renal Transplantation
Enrolment: 396 · Results not recorded
Healthy Volunteers
Enrolment: 33 · Results not recorded
Multiple Sclerosis
Enrolment: 312 · Results not recorded
Relapsing Remitting Multiple Sclerosis
Enrolment: 114 · Results not recorded
Multiple Sclerosis
Enrolment: 600 · Results not recorded
Multiple Sclerosis
Enrolment: 35000 · Results not recorded
Multiple Sclerosis
Enrolment: 4361 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Thoracic spinal cord injury at T6 by 1 minute extradural compression with a modified aneurysm clip, closing force 30 g, after T6 and T7 laminectomy
FTY720 significantly raised the mechanical withdrawal threshold, improved BBB motor score and lowered mortality. It reduced lesion length and volume, decreased circulating CD3 positive lymphocytes at day 3, reduced Iba1 and CD68 positive cells rostral and caudal to the lesion at day 7, reduced fibr…
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Model: Bleomycin-induced acute lung injury and fibrosis
FTY720 given during the inflammatory phase decreased fibrosis by 60% and lung stiffness by 28%, whereas the same dose given during the remodelling phase increased fibrosis 2.1-fold and lung stiffness 1.7-fold, associated with increased connective tissue growth factor but not vascular leakage. Timin…
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Model: Focal cortical cryolesion; separate diffuse trauma model using weight drop contusion injury
FTY720 significantly lowered circulating lymphocyte numbers and attenuated immune cell invasion into damaged brain parenchyma, but did not improve lesion size or functional outcome in either the cryolesion or weight drop model at acute or chronic stages. Blood-brain barrier disruption and neuronal…
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Model: Paraquat poisoning by intraperitoneal instillation of 30 mg/kg, causing acute lung injury progressing to fibrosis
FTY720 attenuated acute lung injury and subsequent fibrosis, lowering lung wet weight to body weight ratio, lavage protein and cytokines at day 3 and downregulating alpha-SMA, TGF-beta, VEGF and collagen I and III at day 28.
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Model: Controlled cortical impact traumatic brain injury with secondary acute lung injury and cardiac dysfunction
Fingolimod reduced inflammatory cytokine production, neutrophil infiltration, bronchoalveolar lavage protein leakage and lung wet/dry weight ratio at 3 days after traumatic brain injury, and reduced cardiac inflammation, apoptosis, fibrosis and histological microstructural change. Cardiac function…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.