Induction of selective liver hypothermia prevents significant ischemia/reperfusion injury in Wistar rats after 24 hours.
RatIschaemia-reperfusionHepaticWistarMalen = 19 rats in total: hypothermia n=7, normothermic ischaemia n…Topical application of cooled saline dropped onto the surface of the anterior liver lobesTarget liver parenchymal temperature 26 degrees C (mean rec…Applied concurrently with the 90-minute ischaemic period, from the start of ped…
Model: Partial (70%) warm hepatic ischemia by atraumatic clamping of the vascular pedicle supplying the anterior lobes for 90 minutes, followed by 24 h reperfusion
Topical hypothermia at 26 degrees C reduced hepatic TNF-alpha (10,900 +/- 1013 versus 15,589 +/- 823 pg/mg, P=0.044), IL-1beta (2833 +/- 91 versus 3538 +/- 211 pg/mg, P=0.009), iNOS (0.267 +/- 0.04 versus 0.435 +/- 0.05, P=0.040) and TNF-alpha/IL-10 ratio (1.46 +/- 0.17 versus 3.20 +/- 0.41, P=0.00…
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