THERAPY DOSSIER · th-daef5e8e90ae

Selective topical liver hypothermia at 26 degrees C

Procedure · Selective topical liver hypothermia (26 C); physical/surgical procedure.

Evidence & regulatory context

Mechanism: Selective topical liver hypothermia (26 C); physical/surgical procedure.
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32428061 ↗2020Reported benefit

Induction of selective liver hypothermia prevents significant ischemia/reperfusion injury in Wistar rats after 24 hours.

RatIschaemia-reperfusionHepaticWistarMalen = 19 rats in total: hypothermia n=7, normothermic ischaemia n…Topical application of cooled saline dropped onto the surface of the anterior liver lobesTarget liver parenchymal temperature 26 degrees C (mean rec…Applied concurrently with the 90-minute ischaemic period, from the start of ped…

Model: Partial (70%) warm hepatic ischemia by atraumatic clamping of the vascular pedicle supplying the anterior lobes for 90 minutes, followed by 24 h reperfusion

Topical hypothermia at 26 degrees C reduced hepatic TNF-alpha (10,900 +/- 1013 versus 15,589 +/- 823 pg/mg, P=0.044), IL-1beta (2833 +/- 91 versus 3538 +/- 211 pg/mg, P=0.009), iNOS (0.267 +/- 0.04 versus 0.435 +/- 0.05, P=0.040) and TNF-alpha/IL-10 ratio (1.46 +/- 0.17 versus 3.20 +/- 0.41, P=0.00…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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