Ghrelin, a novel therapy, corrects cytokine and NF-kappaB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma.

PMID 32426105 ↗2020Reported benefit

Ghrelin, a novel therapy, corrects cytokine and NF-kappaB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma.

MouseRadiationB6D2F1/JFemalen = 6 mice per group per time point across 8 groups (sham, woun…Intravenous, lateral tail vein113 micrograms/kg per injection, in 0.2 mLFirst dose 24 h after irradiation or combined injury

Model: Combined injury: whole-body bilateral cobalt-60 gamma-photon irradiation at 9.5 Gy (0.4 Gy/min) followed within 1 h by a 15% total body surface area full-thickness dorsal skin wound; comparators included radiation alone, wound alone and sham

Ghrelin attenuated combined-injury increases in serum IL-1beta, IL-6, IL-12p70, IL-15, IL-17A, IL-18, MIP-2, eotaxin, G-CSF, GM-CSF, KC and TNF-alpha on day 1, and sustained ileal G-CSF, KC and MIP-1alpha while lowering ileal IL-18. On day 15 it restored villus height and width, crypt depth and cry…

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Ghrelin, a novel therapy, corrects cytokine and NF-kappaB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma.

Evidence by therapy association

Ghrelin, a novel therapy, corrects cytokine and NF-kappaB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma.