Trial title not recorded
Cancer
Enrolment: 30 · Results not recorded
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Hormone
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Cancer
Enrolment: 30 · Results not recorded
Major Depressive Disorder
Enrolment: 26 · Results not recorded
Obesity
Enrolment: 49 · Results not recorded
Metabolism · Insulin Resistance · Hypopituitarism
Enrolment: 8 · Results not recorded
Obesity · Insulin Resistance · Cardiovascular Risk Factor
Enrolment: 40 · Results not recorded
Obesity
Enrolment: 47 · Results not recorded
Dementia
Enrolment: 85 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Combined injury: whole-body bilateral cobalt-60 gamma-photon irradiation at 9.5 Gy (0.4 Gy/min) followed within 1 h by a 15% total body surface area full-thickness dorsal skin wound; comparators included radiation alone, wound alone and sham
Ghrelin attenuated combined-injury increases in serum IL-1beta, IL-6, IL-12p70, IL-15, IL-17A, IL-18, MIP-2, eotaxin, G-CSF, GM-CSF, KC and TNF-alpha on day 1, and sustained ileal G-CSF, KC and MIP-1alpha while lowering ileal IL-18. On day 15 it restored villus height and width, crypt depth and cry…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Traumatic brain injury in mice with secondary acute lung injury
Ghrelin improved lung histology, reduced lung vascular permeability and macrophage influx, and lowered proinflammatory and pyroptosis-related markers after traumatic brain injury.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Radiation combined injury: 9.5 Gy whole-body bilateral cobalt-60 gamma-photon irradiation at 0.4 Gy/min, followed within 1 h by a 15 per cent total body surface area dorsal skin wound under isoflurane
Ghrelin given at 113 micrograms/kg intravenously at 24, 48 and 72 h after combined injury mitigated the rise in sternal adipocytes and fall in megakaryocytes, recovered femur bone marrow cell counts on days 1, 7 and 15, recovered total white blood cells on day 3 with neutrophils and monocytes on da…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Whole-body bilateral Cobalt-60 gamma irradiation at 9.5 Gy (0.4 Gy per minute) followed within 1 hour by a 15% total body surface area dorsal skin burn produced by igniting 0.25 mL of 95% ethanol for 12 seconds
Radiation combined with burn trauma produced cerebro-vascular impairment, intracranial haemorrhage and platelet depletion. Ghrelin given after the combined injury significantly reduced the intracranial haemorrhage score ratio and platelet depletion compared with vehicle.
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Trauma-induced lung contusion causing acute lung injury
Ghrelin significantly reduced morphological lung damage, brought forward the decline in serum adenosine deaminase activity, increased TGF-beta1 and reduced MMP-2 in lung tissue after contusion.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.