Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-kappaB/NLRP3 signaling pathway.
RatChemical/toxinSprague-DawleyMalen = n = 10 per group, five groupsIntraperitoneal1.8 or 3.6 mg/kg body weightPretreatment for 5 days, with the final dose 1 h before cisplatin
Model: Cisplatin-induced acute kidney injury (15 mg/kg cisplatin intraperitoneally)
Omeprazole reduced cisplatin-induced apoptosis and structural kidney damage in vivo and in vitro and inhibited TLR4/NF-kappaB/NLRP3 signalling; the anti-inflammatory effect was blunted by LPS co-treatment in HK-2 cells.
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