Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam.
RabbitChemical/toxinWistar (rats)Male and femaleIntravenous (chloroquine); treatments administered systemicallyAssessed prior to, during and after chloroquine administration
Model: Acute intravenous chloroquine poisoning with cardiotoxicity in anaesthetised rats and rabbits, plus isolated cardiac tissue
Neither diazepam nor other benzodiazepine binding site ligands protected against or attenuated chloroquine cardiotoxicity; diazepam and clonazepam prolonged QTc when given after chloroquine, while diazepam combined with adrenaline improved contractility but caused hypokalaemia.
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