THERAPY DOSSIER · th-bcd3be4070f7

Diazepam (also clonazepam and Ro5-4864)

Drug · GABA-A receptor positive allosteric modulator (benzodiazepine site)

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Evidence & regulatory context

Mechanism: GABA-A receptor positive allosteric modulator (benzodiazepine site)
Target: CHEMBL2093872
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: 1963
Development stage: Not recorded
ChEMBL record: CHEMBL12 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Diazepam; Valium; Valtoco; Diastat; Diazepam intensol; RO 5-2807
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06103188 ↗PHASE3completed

Comparing Melatonin to Diazepam as a Premedication

Anxiety · Preoperative Anxiety

Enrolment: 87 · Results not recorded

NCT03222349 ↗PHASE2completed

Pharmacokinetics and Safety of Diazepam Buccal Soluble Film (DBSF) in Pediatric Subjects With Epilepsy

Epilepsy

Enrolment: 24 · Results not recorded

NCT05361447 ↗PHASE1/PHASE2withdrawn

Efficacy and Safety of Diazepam in GAD65 Associated Epilepsy

GAD 65 Antibody-associated Epilepsy

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32415690 ↗2020No effect reported

Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam.

RabbitChemical/toxinWistar (rats)Male and femaleIntravenous (chloroquine); treatments administered systemicallyAssessed prior to, during and after chloroquine administration

Model: Acute intravenous chloroquine poisoning with cardiotoxicity in anaesthetised rats and rabbits, plus isolated cardiac tissue

Neither diazepam nor other benzodiazepine binding site ligands protected against or attenuated chloroquine cardiotoxicity; diazepam and clonazepam prolonged QTc when given after chloroquine, while diazepam combined with adrenaline improved contractility but caused hypokalaemia.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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