Post-treatment with a heat shock protein 90 inhibitor prevents chronic lung injury and pulmonary fibrosis, following acute exposure of mice to HCl.

Post-treatment with a heat shock protein 90 inhibitor prevents chronic lung injury and pulmonary fibrosis, following acute exposure of mice to HCl.

Model: Intratracheal instillation of 0.1 N hydrochloric acid, 2 microlitre/g body weight, at day 0

AUY-922 started 24 h after acid exposure suppressed sustained inflammation, inhibited profibrotic ERK and HSP90 activation, improved lung function and markedly reduced extracellular matrix accumulation and histological fibrosis.

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