Matrine alleviates neurobehavioral alterations via modulation of JNK-mediated caspase-3 and BDNF/VEGF signaling in a mouse model of burn injury.
MouseBurnUnspecifiedMaleAfter burn injury
Model: Acute thermal burn injury
Matrine improved anxiety-like and depression-like behaviour after burn injury, reduced proinflammatory cytokines, malondialdehyde and nitric oxide in hippocampus and prefrontal cortex, restored antioxidant status, corticosterone and BDNF/VEGF, and downregulated JNK/caspase-3.
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