Lactoferrin Contributes a Renoprotective Effect in Acute Kidney Injury and Early Renal Fibrosis.
MouseChemical/toxinC57BL/6Malen = Five mice per group, four groupsIntraperitonealLow dose 2 mg per mouse; high dose 4 mg per mouseStarting day 2 after folic acid injection
Model: Folic acid-induced acute kidney injury progressing to chronic kidney disease (250 mg/kg folic acid intraperitoneally, single dose at day 0)
Lactoferrin restored body weight, lowered creatinine and blood urea nitrogen, improved renal histology and reduced collagen deposition and alpha-SMA, with increased LC3 and reduced cleaved caspase-3, indicating protection through autophagy induction and apoptosis inhibition.
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