Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea Sequelae
Diarrhea · Wasting · Malnutrition, Child
Enrolment: 600 · Results not recorded
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Biologic · No ChEMBL mechanism-of-action table record. Related ChEMBL entity: talactoferrin alfa (CHEMBL2108651, recombinant human lactoferrin, max_phase 3).
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Diarrhea · Wasting · Malnutrition, Child
Enrolment: 600 · Results not recorded
Diarrhea
Enrolment: 340 · Results not recorded
Severe Sepsis
Enrolment: 1280 · Results not recorded
Sepsis
Enrolment: 190 · Results not recorded
Iron Deficiency Anemia of Pregnancy
Enrolment: 200 · Results not recorded
Iron-deficiency
Enrolment: 288 · Results not recorded
Pneumonia
Enrolment: 72 · Results not recorded
Inflammation · Sarcopenia · Gut Permeability
Enrolment: 60 · Results not recorded
Metallic Taste
Enrolment: 100 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Folic acid-induced acute kidney injury progressing to chronic kidney disease (250 mg/kg folic acid intraperitoneally, single dose at day 0)
Lactoferrin restored body weight, lowered creatinine and blood urea nitrogen, improved renal histology and reduced collagen deposition and alpha-SMA, with increased LC3 and reduced cleaved caspase-3, indicating protection through autophagy induction and apoptosis inhibition.
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Lipopolysaccharide injected into the subcortical white matter of rat pups at postnatal day 3, modelling preterm inflammatory brain injury
Lactoferrin reduced lipopolysaccharide-induced ventriculomegaly, brain tissue loss and microstructural change including myelination deficit, and limited alteration of the 1H-MRS neurochemical profile through an antioxidant action, with less microglial activation. There was no effect on lipopolysacc…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.