Acute effects of human protein S administration after traumatic brain injury in mice.
MouseTBIControlled cortical impactIntravenous1 mg/kg10 to 15 minutes post-injury
Model: Controlled cortical impact traumatic brain injury
A single intravenous dose of protein S given within 15 minutes of controlled cortical impact reduced oedema, improved fine motor coordination, limited progressive tissue loss, suppressed apoptosis and reduced leukocyte infiltration at 24 h.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.