THERAPY DOSSIER · th-b13696f8c9fe

Human protein S

Biologic · Vitamin K-dependent protein S, exogenous protein replacement (EXOGENOUS PROTEIN, direct interaction)

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Vitamin K-dependent protein S, exogenous protein replacement (EXOGENOUS PROTEIN, direct interaction)
Target: CHEMBL5498501 (vitamin K-dependent protein S)
Injury models: TBI
Reported indication: Not recorded
First approval: 2023
Development stage: Not recorded
ChEMBL record: CHEMBL6068491 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Protein S; Protein S human component of Balfaxar
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00005329 ↗Phase not recordedcompleted

Protein S and myocardial infarction

Cardiovascular Diseases · Myocardial Infarction

Enrolment not recorded · Results not recorded

NCT03589430 ↗Phase not recordedunknown

Haemostatic imbalance in chronic liver disease (protein C, protein S, antithrombin III)

Haemostasis Imbalance in Chronic Liver Disease

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32394965 ↗2020Reported benefit

Acute effects of human protein S administration after traumatic brain injury in mice.

MouseTBIControlled cortical impactIntravenous1 mg/kg10 to 15 minutes post-injury

Model: Controlled cortical impact traumatic brain injury

A single intravenous dose of protein S given within 15 minutes of controlled cortical impact reduced oedema, improved fine motor coordination, limited progressive tissue loss, suppressed apoptosis and reduced leukocyte infiltration at 24 h.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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