PRECLINICAL PUBLICATION · 2020

scAAV2-Mediated C3 Transferase Gene Therapy in a Rat Model with Retinal Ischemia/Reperfusion Injuries.

Rat / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Self-complementary AAV2 vector encoding exoenzyme C3 transferase (scAAV2-C3)

PMID 32382585 ↗2020Reported benefit

scAAV2-Mediated C3 Transferase Gene Therapy in a Rat Model with Retinal Ischemia/Reperfusion Injuries.

RatIschaemia-reperfusionOther / unspecifiedIntravitreal injection7 days before ischaemia/reperfusion injury

Model: Retinal ischaemia/reperfusion injury induced by acute ocular hypertension

scAAV2-C3 significantly reduced apoptotic retinal ganglion cells and cell loss in the ganglion cell layer after ischaemia/reperfusion, and treated retinas were the thickest among injured groups.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.