Phase 2b/3 placebo-controlled study of VX-210 (C3 transferase) in acute traumatic cervical spinal cord injury
Cervical Spinal Cord Injury
Enrolment: 70 · Results not recorded
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Biologic · Gene-therapy vector driving sustained neuronal expression of Clostridium botulinum exoenzyme C3 transferase, which ADP-ribosylates RhoA/B/C at Asn41 and inactivates Rho-ROCK signalling, relieving myelin- and CSPG-mediated inhibition of axon growth. No ChEMBL entity exists for the vector or the bacterial enzyme.
4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Cervical Spinal Cord Injury
Enrolment: 70 · Results not recorded
Spinal Cord Injury
Enrolment: 0 · Results not recorded
Acute Cervical Spinal Cord Injury
Enrolment: 0 · Results not recorded
Spinal Cord Injury
Enrolment: 48 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Retinal ischaemia/reperfusion injury induced by acute ocular hypertension
scAAV2-C3 significantly reduced apoptotic retinal ganglion cells and cell loss in the ganglion cell layer after ischaemia/reperfusion, and treated retinas were the thickest among injured groups.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.