Pharmacological Transection of Brain-Spinal Cord Communication Blocks Pain-Induced Hemorrhage and Locomotor Deficits after Spinal Cord Injury in Rats.
RatSpinal cord injuryContusionSprague-DawleySlow spinal infusion at T2; also delivered by lumbar puncture at the injury siteInfused 24 h post-injury, immediately before or immediately after noxious stimu…
Model: Lower thoracic (T12) contusion spinal cord injury followed 24 h later by noxious electrical stimulation of the tail
Noxious stimulation 24 h after contusion impaired locomotor recovery and increased haemorrhage; lidocaine applied rostrally at T2 before, but not immediately after, stimulation blocked both effects, with a similar pattern after lumbar puncture delivery at the injury site.
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