THERAPY DOSSIER · th-e81bacb25b59

Lidocaine

Drug · BLOCKER of the voltage-gated sodium channel alpha subunit (local anaesthetic; also class Ib antiarrhythmic).

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: BLOCKER of the voltage-gated sodium channel alpha subunit (local anaesthetic; also class Ib antiarrhythmic).
Target: CHEMBL2331043
Injury models: Other · Wound · Spinal cord injury · TBI · Radiation
Reported indication: Not recorded
First approval: 1948
Development stage: Not recorded
ChEMBL record: CHEMBL79 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Lidocaine; Lignocaine; Xylocaine; Lidoderm; Octocaine; Ztlido; NSC-40030
Note: Not recorded

Clinical trials 11

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03195413 ↗Injury indicationNAcompleted

Early ultrasound-guided forearm nerve block for painful hand injuries in the emergency department, using a 1:1 mixture of 1% lidocaine and 0.5% bupivacaine

Hand Injuries · Hand Injuries and Disorders

Enrolment: 15 · Results not recorded

NCT07273006 ↗PHASE4not yet recruiting

Percutaneous Electrical Nerve Stimulation as Alternative to Lidocaine Nerve Blocks in Chronic Pain

Non-specific Low Back Pain · Facet Joint Syndrome

Enrolment: 82 · Results not recorded

NCT04766684 ↗PHASE4completed

Local Anesthetic Options for Clubfoot Tenotomy: Needle-Free Jet Lidocaine Versus Topical Liposomal Lidocaine Cream

Clubfoot

Enrolment: 107 · Results not recorded

NCT05767749 ↗PHASE4completed

Comparing Duration of Local Anesthetic (Lidocaine, Ropivacaine, Bupivacaine) in Dermatologic Surgery

Anesthetics, Local

Enrolment: 75 · Results not recorded

NCT00247741 ↗PHASE3completed

Spinal Anesthesia With Articaine and Lidocaine for Outpatient Surgery

Spinal Anesthesia

Enrolment: 80 · Results not recorded

NCT03238625 ↗PHASE2completed

Painless Local Anaesthesia With Lidocaine Bicarbonate Admixture

Local Infiltration · Anesthesia

Enrolment: 48 · Results not recorded

NCT06243120 ↗EARLY_PHASE1unknown

Intravenous Lidocaine for Treating Intrathecal Fentanyl Induced Pruritus

Pruritus Caused by Drug

Enrolment: 54 · Results not recorded

NCT05742438 ↗NAcompleted

Dexmedetomidine, Lidocaine Infusion and Intrathecal Morphine on Perioperative Stress/Immune Biomarkers in Colorectal Cancer Surgery

Colorectal Cancer · Anesthesia · Cancer Metastatic · Inflammation

Enrolment: 114 · Results not recorded

NCT00992914 ↗NAcompleted

Stellate Ganglion Injection With 1% Lidocaine for Relief From Hot Flushes

Hot Flashes · Menopause

Enrolment: 40 · Results not recorded

NCT02678585 ↗NAcompleted

Nalbuphine as an Adjuvant to Lidocaine Intravenous Regional Anesthesia

Postoperative Pain

Enrolment: 106 · Results not recorded

NCT01192490 ↗NAunknown

Topical Lidocaine on the Cervix Prior to Insertion of Intrauterine Devices

Contraception

Enrolment: 210 · Results not recorded

Preclinical evidence 7

4 studies reported at therapy level; 7 evidence entries itemised.

PMID 21676267 ↗2011Reported benefit

Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav1.3 expression and decreasing spinal microglial activation.

RatOtherSprague-DawleyMalen = 66Intrathecal2% lidocaine, 50 microLPretreatment (before nerve injury)

Model: L5 spinal nerve ligation (neuropathic pain)

Intrathecal lidocaine pretreatment attenuated acute neuropathic pain after spinal nerve ligation by reducing Nav1.3 upregulation and spinal microglial activation, with effects lasting 3 days.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

PMID 22846953 ↗2012No effect reported

Effect of local anesthetic on microorganisms in a murine model of surgical site infection.

MouseWoundFemaleSubcutaneous infiltration of the woundBefore surgical incision (pre-injury infiltration)

Model: Surgical wound infection model with Staphylococcus aureus and Escherichia coli inoculation of surgical wounds

Infiltration with saline, lidocaine or lidocaine mixed with bupivacaine did not produce significantly different bacterial presence or degree of inflammation once experimental condition of the bacterial inocula was controlled for; pre-incision local anaesthetic did not reduce bacterial growth or alt…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 32368946 ↗2020Reported benefit

Pharmacological Transection of Brain-Spinal Cord Communication Blocks Pain-Induced Hemorrhage and Locomotor Deficits after Spinal Cord Injury in Rats.

RatSpinal cord injuryContusionSprague-DawleySlow spinal infusion at T2; also delivered by lumbar puncture at the injury siteInfused 24 h post-injury, immediately before or immediately after noxious stimu…

Model: Lower thoracic (T12) contusion spinal cord injury followed 24 h later by noxious electrical stimulation of the tail

Noxious stimulation 24 h after contusion impaired locomotor recovery and increased haemorrhage; lidocaine applied rostrally at T2 before, but not immediately after, stimulation blocked both effects, with a similar pattern after lumbar puncture delivery at the injury site.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

PMID 26742649 ↗2016Reported harm

Effects of lidocaine on torn rotator cuff tendons.

RatOtherSprague-DawleyIntra-articular subacromial shoulder injection0.1 per cent lidocaine used in vitro; injected volume and c…Injected at the time of surgery before wound closure

Model: Surgically created acute supraspinatus tendon tear in bilateral shoulders, with paired human tenocyte culture experiments

Lidocaine was cytotoxic to tenocytes, reduced ultimate load to failure and stiffness, induced tenocyte apoptosis and delayed collagen organisation in a rat rotator cuff tear model.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 7783235 ↗1995

The effect of acute cocaine or lidocaine on behavioral function following fluid percussion brain injury in rats

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 2324798 ↗1990

Reduction in radiation-induced brain injury by use of pentobarbital or lidocaine protection

RatRadiation

Extraction: mesh. Machine-extracted fields require source verification.

PMID 8628582 ↗1995

Effects of intrathecal local anesthetics on spinal excitability and on the development of autotomy

RatOther

Extraction: mesh. Machine-extracted fields require source verification.

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