The neuroregenerative effects of topical decorin on the injured mouse cornea.
MouseWoundC57BL/6J; Cx3cr1 mice lacking resident corneal epithelial dendritic cellsTopicalAfter abrasion, with a separate prophylactic arm applied before abrasion
Model: Bilateral central corneal epithelial abrasion, 2 mm, using an Alger Brush
Topical decorin increased intraepithelial dendritic cell recruitment at 6 h without altering re-epithelialisation, and by one week raised sub-basal nerve plexus and superficial terminal density in the central cornea while lowering stromal macrophage density; no improvement occurred in mice lacking…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.