Intravitreal decorin preventing proliferative vitreoretinopathy in perforating injuries
Proliferative Vitreoretinopathy
Enrolment: 15 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Proliferative Vitreoretinopathy
Enrolment: 15 · Results not recorded
Primary Open-angle Glaucoma
Enrolment: 52 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Adult cerebral cortex traumatic scar tissue
Decorin infusion significantly reduced semaphorin 3A mRNA and protein expression in cortical scar tissue.
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Model: Corneal injury and scarring; a rat model was used for gel retention and a corneal organ culture model was used to assess re-epithelialisation
The fluid gel gave enhanced decorin release compared with a conventional gel film, was retained on the ocular surface in vivo in rats, and significantly increased re-epithelialisation within four days of treatment in an organ culture model (P less than 0.05).
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Model: Bilateral central corneal epithelial abrasion, 2 mm, using an Alger Brush
Topical decorin increased intraepithelial dendritic cell recruitment at 6 h without altering re-epithelialisation, and by one week raised sub-basal nerve plexus and superficial terminal density in the central cornea while lowering stromal macrophage density; no improvement occurred in mice lacking…
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Model: Dorsal funicular spinal cord lesion, treated in both the acute and the chronic phase
In acute lesions decorin reduced wound cavity area by 68 per cent, glia limitans accessoria encapsulation by 65 per cent, basal lamina thickness by 94 per cent and macrophage and microglial accumulation by 60 per cent, with smaller reductions in chronic lesions (cavity area 11 per cent, encapsulati…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.