Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways.
MouseIschaemia-reperfusionRenalC57BL/6J (SPF)Malen = 6 mice per group, 3 groups, 18 mice in totalIntraperitoneal15 mg/kg/dayDaily from the day of model induction
Model: Bilateral renal artery ischaemia for 30 min followed by reperfusion, under pentobarbital sodium anaesthesia (50 mg/kg), body temperature maintained at 37 C
Oridonin significantly reduced serum creatinine and blood urea nitrogen relative to untreated ischaemia-reperfusion injury, and lowered tubular damage, renal macrophage infiltration and pro-inflammatory cytokine expression, with reduced AKT phosphorylation. Absolute values were not reported in the…
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