Nutraceutical · ent-kaurane diterpenoid from Rabdosia rubescens. ChEMBL holds the compound record (max_phase -1, unknown clinical phase, natural product flag set) but NO mechanism-of-action record, so moa_list is empty. The mechanism invoked in the trauma literature and in the one human trial found is covalent binding to NLRP3 at Cys279, blocking NLRP3-NEK7 interaction and inflammasome assembly.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
NLRP3 · hsCRP · Percutaneous Coronary Intervention
Enrolment: 132 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Bilateral renal artery ischaemia for 30 min followed by reperfusion, under pentobarbital sodium anaesthesia (50 mg/kg), body temperature maintained at 37 C
Oridonin significantly reduced serum creatinine and blood urea nitrogen relative to untreated ischaemia-reperfusion injury, and lowered tubular damage, renal macrophage infiltration and pro-inflammatory cytokine expression, with reduced AKT phosphorylation. Absolute values were not reported in the…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
