Changes of DNA synthesis in brain cortical cells after transplantation of embryonic nervous tissue into the brain of rats after hypoxia.
RatOtherInbred strain (not further specified)FemaleIntracerebral transplantationAfter hypoxic insult
Model: Acute hypoxic hypoxia causing mass dystrophy of cortical neurons
Transplantation stimulated DNA synthesis in non-neuronal cells (glia, macrophages, endothelial cells), more so in the operated hemisphere and more in intact than in hypoxia-exposed rats. DNA synthesis was essentially absent in neurons apart from occasional cells near the wound canal and transplant.
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